IU School of Medicine

Elective Title: 93SG770 — RESEARCH - ORGAN TRANSPLANTATION

Description:

A. Xenotransplantation- 100,000 people wait for solid organ transplantation in the United States. The use of genetically engineered pig organs could eliminate this shortage. Our lab is focused on two main projects: a. Xenoimmunology- identifying mechanisms of rejection of pig organs so that we can genetically engineer pig organs that will not be rejected by the human immune system. Specifically we are identifying target xenoantigens that are bound by human antibodies using state of the art proteomics and mass spectometry that can be knocked out in donor pigs. Additionally, we are identifying the mechanism by which the pig liver phagocytosis human platelets so that we can devise genetic engineering strategies to eliminate this barrier to clinical liver xenotransplantation. b. Genetic Engineering of Donor Pigs- we are creating genetically engineered pigs that are less susceptible to rejection by the human immune system than wild type pigs. B.Clinical Research- we have databases for each of our abdominal transplant programs so that we can figure out the latest information regarding standards of patient care.

Elective Details:

Primary Contact for Add/Drops: Megan Rendina (mrendina@iupui.edu)

Director: Changrashekar Kubal, M.D.

Campus: Indianapolis

Location: IU Health University Hospital (Indianapolis)

Other Faculty: Dr. Burlak, Dr. Mangus

Learning Objectives

  • 1) Develop a focused research hypothesis and outline techniques to test the research question (PBLI1)
  • 2) Perform the necessary methodology or techniques relative to the student research project (if applicable) (PBLI1)
  • 3) Discuss relevant data in the context of the student research project (PBLI1)
  • 4) Prepare a summation of the clinical/basic science research project in abstract and manuscript form (ISC5)

Assessment

  • Research Evaluation Form; (Observations)

Enrollment Information

Prerequisites: 3rd or 4th year status; Surgery clerkship must be completed; interest in research.

Availability with Max Students per Month:

JuneJulyAugSeptOctNovDecJanFebMarAprMay
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Duty Hours: 70

Time Distribution: 75% Research; 5% Lecture; 20% Library

Elective Type Category: AS - Advanced Science

Notes and Enrollment Information:

All on-campus surgery electives will be handled through the match. Post-match results, all additions and drops for surgery electives must be approved through Megan Rendina, Surgery Clerkship Coordinator at 274-7201 or mrendina@iupui.edu.

Third Year Elective? Yes

Interprofessional Skills and Service Learning

Interprofessional Collaborative Skills: None

Service Learning Included: None