Research interests include regulation of CB1 cannabinoid receptor signaling, regulation of endocannabinoid production, role of endocannabinoids in synaptic plasticity, and novel cannabinoid receptors.

The Mackie lab examines the role and function of the endocannabinoid system by using a combination of electrophysiological, imaging, biochemical and immunological approaches. The endocannabinoid system is comprised of cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes that regulate the production and degradation of endocannabinoids. ?9THC, the principal psychoactive component of cannabis, interacts with this system to produce the classic effects of cannabis intoxication. In addition, this system is widely involved in multiple physiologically important processes including memory, motivation, movement, analgesia, and emesis. "Through our studies, we hope to better understand the implications of social and therapeutic use of drugs that influence this fascinating system."