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Faculty/Research < Faculty Research Profiles < Environmental Science Faculty

Environmental Science Faculty


Diane Henshel
Associate Professor

Ph.D., Neurobiology, Washington University, 1987




Professor Henshel's interests focus on the sublethal health effects of environmental pollutants, especially on pollutant effects on the developing organism. Recent research has emphasized the effects of polychlorinated dibenzo-p-dioxins (PCDDs) and related congeners on the developing avian nervous system using a combination of neuroanatomical, immunohistological, biochemical and behavioral techniques. In order to understand the environmental implications of these effects, she studies both animals exposed in the wild, and animals exposed to known concentrations under controlled conditions in the laboratory. The studies are designed for ultimate use in improved risk assessment procedures.

The laboratory has two main foci:
  1. Characterization of the effects of PCBs and other environmental endocrine disruptors on wildlife development, focusing especially on birds and fish.
  2. Characterization and understanding the mechanisms underlying the ameliorative effects of high intensity red LED light on oxidative stress-related toxicity.

Outside the laboratory her recent research has involved the use of data mining techniques as a landscape level screening tool to investigate the linkage between exposure to environmental chemicals and public health impacts.

Her teaching interests lie in the fields of developmental toxicology, risk assessment and risk communication.


Awards

Recent Publications

Lim, J., DeWitt, J.C., Sanders, R.A., Watkins III, J.B., and Henshel, D.S. (2007). Suppression of endogenous antioxidant enzymes by 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced oxidative stress in chicken liver during development. Arch. Environ. Contam. Toxicol. In press.

Yeager, R.L., Lim, J., Millsap, D.S., Jasevicius, A.V., Sanders, R.A., Whelan, H.T., Watkins, J.B.III, Eells, J.T., Henshel, D.S. (2006). 670 nm Light Treatment Attenuates Dioxin Toxicity in the Developing Chick Embryo. J. Biochem. Molec. Toxicol. In press (expected publication date: Dec. 2006).

Yeager, R.L., Oleske, D.A., Millsap, D.S., Henshel, D.S. (2006). Severe craniofacial malformations resulting from developmental exposure to dioxin. Repro Toxicol. In press (on-line 7/22/06; expected publication date: Dec. 2006).

DeSmet, K.D.,  Paz, D.A.,Eells, J.T., Wong-Riley, M.T.T., Henry, M.M., Buchmann, E.V., Connelly, M.P., Dovi, J.V., Liang, H.L.,  Henshel, D.S., Yeager, R.L., Millsap, D.S, Lim, J., Gould, L.J., Das, R., Jett, M., Hodgson, B.D., Margolis, D., Whelan, H.T. (2006). Clinical and Experimental Applications of NIR-LED Photobiomodulation. Photomed Laser Surgery 24(2):121-128.

Yeager, R.L., Franzosa, J.A., Millsap, D.S., Angell-Yeager, J.L., Heise, S.S., Wakhungu, P. Lim, J,  Whelan, H.T., Eells, J.T., Henshel, D.S. (2006). Embryonic Growth and Hatching Implications of Developmental 670 nm Phototherapy – Dioxin Co-Exposure.  Photomed Laser Surgery 24(3): 410-413.

DeWitt, J., Millsap, D.M., Yeager, R.L., Heise, S.S., Sparks, D.W., and Henshel, D.S. (2006).  External heart deformities in passerine birds exposed to environmental mixtures of PCBs during development. Environ Toxicol Chem 25(2): 541-551.

Yeager, R.L.,  Franzosa, J.A.,  Millsap, D.S., Lim, J., Heise, S.S., Wakhungu, P., Whelan, H.T.,  Eells, J.T., and  Henshel, D.S. (2006).  Survivorship and Mortality Implications of Developmental 670 nm Phototherapy – Dioxin Co-Exposure. Photomedicine and Laser Surgery 24:29-32.

Henshel, D.S., Sparks, D.W.,  Simon, T.P., and  Tosick, M.J. (2006). Age Structure and Growth of Creek chub (Semotilus atromaculatus) (Mitchill) in PCB-contaminated streams in Indiana. J. Fish Biol. 68:44–62 doi:10.1111/j.1095-8649.2005.00875.x

Boeglin, M.L., Wessels, D., and Henshel, D.S.  (2006). An investigation of the relationship between air emissions of volatile organic compounds and incidence of cancer in Indiana counties. Environ Res 100(2):242-254.  doi:10.1016/j.envres.2005.04.004.

Henshel, D.S and Sparks, D.W. (2006). Site-specific PCB-linked Interspecies Differences in Organ Somatic Indices. Ecotoxicology 15:9-18. DOI: 10.1007/s10646-005-0038-0.

Yeager, R.L., Franzosa, J.A., Millsap, D.S., Angell-Yeager, J.L., Heise, S.S., Wakhungu, P. Lim, J,  Whelan, H.T., Eells, J.T., Henshel, D.S. (2005). Effects of 670 nm Phototherapy on Development.  Photomedicine and Laser Surgery 23:268-272.

DeWitt, J.C., Meyer, E.B., Henshel, D.S. (2005). Environmental toxicity studies using chickens as surrogates for wildlife: Effects of vehicle volume. Arch Environ Contam Toxicol  48(2):260-269.

DeWitt, J.C., Meyer, E.B., Henshel, D.S. (2005). Environmental toxicity studies using chickens as surrogates for wildlife: Effects of injection day. Arch Environ Contam Toxicol  48(2):270-277.

Henshel, D.S., DeWitt, J., and Troutman, A. (2002). Chicken Embryos for Teratology Studies, Current Protocols in Toxicology. In M.D. Maines (Ed.). J Wiley and Sons, Sec. 13.4.

Boischio, A.A.P. and Henshel, D.S. (2000). Linear regression models on methyl mercury exposure during prenatal and early postnatal life among riverside people along the Upper Madeira River, Amazon. Environmental Research Section A 83(2): 150-61.

Boischio, A.A.P.  and Henshel, D.S. (2000) Fish consumption, fish lore and mercury pollution - Risk communication for the Madeira River people.  Environmental Research Section A 84:108-126.

Boischio, A.A.P., Cernichiari, E., Henshel, D. (2000). Segmental hair mercury evaluation of a single family along the Upper Madeira Basin, Brazilian Amazon. Reports in Public Health (Cadernos de Saude Publica) 16(3):681-6.

Henshel, D.S. (1998). Developmental and neurotoxic effects of dioxin and dioxin-like compounds on domestic and wild avian species. Environmental Toxicology and Chemistry 17(1):88-98 .

D.S. Henshel, B. Hehn, R. Wagey, M. Vo, J.D. Steeves. (1997). The relative sensitivity of chicken embryos to yolk or aircell - injected 2,3,7,8 - tetrachlorodibenzo-p-dioxin. Environmental Toxicology and Chemistry 16(4):725-732.

Henshel, D.S., Martin, J.W., DeWitt, J.C. (1997). Brain Asymmetry as a Potential Biomarker for Developmental TCDD Intoxication: A Dose-Response Study. Environmental Health Perspectives, 105(7):718-725.

A.A.P. Boschio and D.S. Henshel. (1996). Risk Assessment of Mercury Exposure Through Risk Consumption by the Riverside People in the Madeira Basin, Amazon, 1991  Neurotoxicology 17(1): 169-176.

D.S. Henshel, M.T. Vo, B. Hehn, and J.D. Steeves. (1993). A short-term test for dioxin teratogenicity using chicken embryos,  In J. Hughes et al. (Eds.), ASTM STP #1173: Second Symposium on Environmental Toxicology and Risk Assessment. American Society for Testing and Materials (ASTM), Philadelphia. pp. 159-174.



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